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Iranian Heart Journal، جلد ۱۱، شماره ۳، صفحات ۲۹-۳۶
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عنوان انگلیسی MYOCARDIAL CONTRACTILE RESERVE ACCURATELY PREDICTS POSITIVE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY
چکیده انگلیسی مقاله Background: Up to 30% of patients with heart failure fail to respond to cardiac resynchronization therapy. This study was aimed at assessing the role of low-dose dobutamine stress echocardiography along with tissue Doppler imaging indices to predict response to cardiac resynchronization therapy.Methods: Twenty-one consecutive patients with systolic heart failure who were candidates for cardiac resynchronization therapy were prospectively included. Contractile reserve was assessed by low-dose dobutamine stress echocardiography (cut-off: 5 and 10%). Interventricular and intraventricular dyssynchrony (using 6 basal, 6 mid-segmental models) was assessed. Acute post-cardiac resynchronization therapy response was defined by 15% or more decrease in the left ventricular end systolic volume. Sensitivity, specificity, predictive values, and likelihood ratios were calculated for the tests singly and in combination.Results: Low-dose dobutamine stress echocardiography had the highest specificity (80%) and positive likelihood ratio (2.5), but interventricular dyssynchrony exhibited the highest sensitivity (83.3%) and the lowest negative likelihood ratio (0.4) for predicting positive response to CRT.Conclusion: Inotropic contractile reserve assessed by low-dose dobutamine stress echocardiography strongly predicts acute response to cardiac resynchronization therap.
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نویسندگان مقاله MARYAM ESMAEILZADEH |


ROYA SATTARZADEH BADKOUBEH |
TEHRAN UNIVERSITY OF MEDICAL SCIENCES

MAJID HAGHJOO |


MAJID, MALEKI |


FERIDOUN NOOHI |


ANAHITA GHORBANI |


نشانی اینترنتی http://journal.iha.org.ir/article_83717_1f7ca629ad10b0ad9ae7b4eca23644c6.pdf
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