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Veterinary Research Forum، جلد ۷، شماره ۱، صفحات ۷۹-۸۳
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عنوان انگلیسی Large B-cell lymphoma in a dog: A cyto-histopathological evaluation and Immunophenotyping according to WHO classification for canine lymphomas
چکیده انگلیسی مقاله In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an 8-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of centroblasts, immunoblast and medium-sized cells. Histopathologically, the follicles and sinuses of lymph nodes were replaced by sheets of numerous immunoblasts (less than 90.0% of total cells) and centroblasts. Numerous mitotic figures were also observed. Immunohistochemical analysis presented that the neoplastic cells express B-cell phenotype CD20 and CD79a, but do not stain for T phenotype CD3. On the basis of cytology, histopathology and immunohistochemical findings, the present tumor was diagnosed as diffuse large B-cell lymphoma, high-grade centroblastic type (DLBCL-CB) according to WHO histological classification. Applying this classification system for diagnosis of canine lymphomas is very useful and has a high accuracy and consistency. However, further co-operative studies between clinicians and pathologists should be performed, in order to improve the effectiveness of this classification.
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نویسندگان مقاله زهرا نیکوصفت |
department of clinical sciences, school of veterinary medicine, razi university, kermanshah, iran
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

محمد هاشم نیا |
department of pathobiology, school of veterinary medicine, razi university, kermanshah, iran
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

موسی جاودانی |
department of clinical sciences, faculty of veterinary medicine, shahrekord university, shahrekord, iran

نشانی اینترنتی http://vrf.iranjournals.ir/article_19049_a829fe45b171c7b1f4380aee26ab1dbe.pdf
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