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Middle East Journal of Cancer، جلد ۳، شماره ۴، صفحات ۱۳۱-۱۴۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study |
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| چکیده انگلیسی مقاله |
Background: We conducted a retrospective analysis to investigate the clinical outcome of combined modality therapy using multiagent chemotherapy, nephrectomy, and radiotherapy in treatment of children with Wilms' tumor.Methods: This study was conducted on 91 cases of newly diagnosed Wilms' tumor from January 2001 until February 2012. Patients were categorized into two groups according to treatment approach: i) preoperative chemotherapy with delayed surgery (group A; n=66) and ii) immediate surgery (group B; n=25).Results: Preoperative chemotherapy showed a 54.5% partial response rate in group A patients. A final stage distribution indicated that the majority of patients (64%) from both groups were considered to be in the early disease stages (I and II). The median follow up was 49 months (range 3-124). The five-year overall survival rate was 66.5%, whereas the event-free survival rate was 62.5%. In univariate analysis, factors associated with statistically significant reduction in overall (P24 months was associated with a significant reduction in the overall survival rate (P=0.038, HR: 0.438, 95% CI: 0.192-0.953), but was not significant in terms of event- free survival (P=0.104, HR: 0.539, 95% CI: 0.256-1.136). Age >24 months (P=0.0095), disease stage (P=0.0014), and blastimal subtype (P=0.006) were associated with significant increases in relapse rate.Conclusion: Preoperative chemotherapy resulted in a final stage redistribution that placed the majority of patients in the early stages of the disease. Age at diagnosis, disease stage, and histological subtype significantly affected survival and relapse rates. |
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| نویسندگان مقاله |
Heba A. Sayed |
Pediatric Oncology Department, South Egypt Cancer Institute (SECI), Assiut University,
Assiut, Egypt
Mona M. Sayed |
Radiation Oncology Department, South Egypt Cancer Institute (SECI), Assiut University,
Assiut, Egypt
Mohamed I. El-Sayed |
Radiation Oncology Department, South Egypt Cancer Institute (SECI), Assiut University,
Assiut, Egypt
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/article_41853_2d5e4fdb2db2c392df7bd41340ccd8e7.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-1411298.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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