| چکیده انگلیسی مقاله |
Background: The healthcare and socio-economic burden resulting from influenza A (H1N1) pdm09 in Spain was considerable. Our aim was to estimate and compare the management (resource utilization) and economic healthcare impact in an at-risk group of unvaccinated pregnant women with an unvaccinated group of non-pregnant woman of childbearing age (15-44 yr old). Methods: We addressed this question with a longitudinal, observational, multicentre study. Inputs were the requirements in managing both groups of women. Outcome measures were healthcare costs. Direct healthcare (including medical utilisation, prescriptions of antivirals, medication, diagnostic tests, and hospitalisation) costs and indirect (productivity loss) costs were considered. Unit of cost was attributed to the frequency of health service resources utilisation. The mean cost per patient was calculated in this group of women. Results: We found that the influenza clinical pattern was worse in non-pregnant women as they had a high medical risk of 20.4% versus 6.1% of pregnant women. Non-pregnant required more antipyretics and antibiotics, and needed more health service resource utilisation (338 medical visits in non-pregnant women vs. 42 in pregnant women). The total cost of non-pregnant women was higher (€4,689.4/non-pregnant and €2,945.07/pregnant). Conclusions: Cost per (H1N1) pdm09 was lower for pregnant women, probably due to more preventive measures adopted for their protection in Spain. The highest costs were incurred by hospitalisations/day and work absenteeism for non-pregnant than for pregnant women. These data will allow better future pandemic influenza planning. |
| نویسندگان مقاله |
| María MORALES-SUÁREZ-VARELA
Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46010 Valencia, Spain
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Center for Public Health Research (CSISP-FISABIO), Valencia, Spain
| Agustín LLOPIS-GONZÁLEZ
Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46010 Valencia, Spain
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Center for Public Health Research (CSISP-FISABIO), Valencia, Spain
| Fernando GONZÁLEZ-CANDELA
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Research Unit “Genomics and Health” CSISP-University of Valencia, Spain
| Jenaro ASTRAY
Surveillance Branch, Community of Madrid, Spain
| Jordi ALONSO
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
University Pompeu Fabra, Barcelona, Spain
Institute for Research IMIM-Hospital del Mar, Spain
| Olatz GARIN
CIBER Respiratory Diseases, Spain
| Ady CASTRO
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Ramón y Cajal University Hospital, Madrid, Spain
| Juan Carlos GALAN
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
University of Girona, Spain
| Nuria SOLDEVILA
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Public Health Institute of Navarra, Spain
| Jesús CASTILLA
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Dept. of Health, Generalitat of Catalonia, Spain
| Pere GO­DOY
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
University of Jaen, Spain
| Miguel DELGADO-RODRÍGUEZ
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
University of León, Spain
| Vicente MARTIN
Security Service of Andalusia, Spain
| Jose María MAYORAL
Red Española de Investigación en Patología Infecciosa (REIPI), Spain
| Tomas PUMAROLA
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Basque Fundation for Health Innovation and Research, Spain
| José Maria QUINTANA
Dept. of Public Health, Development and Innovation, Junta de Castilla y León, Spain
| Sonia TAMAMES
Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46010 Valencia, Spain CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Center for Public Health Research (CSISP-FISABIO), Valencia, Spain
| Nu­ria RUBIO-LÓPEZ
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Dept. of Public Health, University of Barcelona, Spain
| Angela DOMINGUEZ
CIBER Epidemiologia y Salud Pública (CIBERESP), Spain 
Dept. of Public Health, University of Barcelona, Spain
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