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Iranian Journal of Public Health، جلد ۴۵، شماره ۵، صفحات ۵۹۶-۶۰۵
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عنوان انگلیسی Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China
چکیده انگلیسی مقاله Background: Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed to explore SUA among patients suffering from these diseases to enhance the hypothesis. Methods: Overall, 1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode. Results: From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (P=0.011), 5.88umol/L (P=0.014) and 9.39 umol/L (P=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (P=0.003). Conclusion: Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.    
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نویسندگان مقاله | Qicai CHEN
Dept. of Prevention and Health Care, Dongying Shengli Oilfield Central Hospital, Dongying, China


| Juan XIAO
Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China


| Pengpeng ZHANG
Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China
 Tianjin Entry-Exit Inspections and Quarantine Bureau, Tianjin, China


| Lili CHEN
Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China
 Dept. of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou, China


| Xiaoxiao CHEN
Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China


| Shumei WANG
Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/6795
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