این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۴۷، شماره ۷، صفحات ۹۷۳-۹۷۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Haplotype Analysis of Peroxisome Proliferator-activated Recep-tor γ Gene Polymorphisms and the Lipoprotein (a) Level
چکیده انگلیسی مقاله   Background: Lipoprotein (a) [Lp(a)], as an independent risk factor for cardiovascular disease, is more likely to be genetically determined according to the increasing evidence of epidemiologic and clinical studies in recent years. Peroxisome proliferator-activated receptor (PPAR)γ, the ligand-activated transcription factors, was considered as an indispensable role in the process of lipid metabolism. This study was designed to explore the associations of three single-nucleotide polymorphisms (SNPs) and the haplotypes of the peroxisome proliferator-activated receptor (PPAR)γ gene with the level of Lp(a). Methods: Participants were recruited under the framework of the PMMJS (The Prevention of Metabolic Syndrome (MS) and Multi-metabolic Disorders in Jiangsu Province of China Study) from Apr 1999 to Jun 2004. Overall, 644 subjects were randomly selected and 3 SNPs of PPARγ gene (rs10865710, rs1805192, rs4684847) were genotyped. Results: After adjusting for age, sex, cigarette smoking, alcohol drinking, waist circumference and body mass index, rs4684847 was significantly associated with Lp (a). The presence of the rs4684847 T allele (CT+TT) have a lower level of Lp (a) than the allele (CC) in the dominant model, mean difference was -27.30 (95%CI:-52.88~-1.73) mg/L, P< 0.05. G-P-T and G-A-T haplotype were associated with lower levels of Lp (a) (P=0.0041 and< 0.0001), mean difference was 49.79(95%CI:-97.52~-2.06) mg/L and 17.75(95%CI:-25.75~-9.75) mg/L. Conclusion: PPAR gamma polymorphisms (rs10865710, rs1805192, rs4684847) and haplotypes may be the genetic risk factors for Lp (a) level.    
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Chao SHEN
Dept. of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China The Center for Disease Control and Prevention of Suzhou Industry Park, SuZhou, China


| Wei FAN
Dept. of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China


| Hui-Jian XIE
Dept. of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China


| Ming WU
Center for Disease Control, Nanjing, Jiangsu Province, China


| Zheng-Yuan ZHOU
Center for Disease Control of Changshu, Suzhou, China


| Zhi-Rong GUO
Dept. of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China


| Chen DONG
Dept. of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/14041
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354188.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات