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Iranian Journal of Public Health، جلد ۴۸، شماره ۳، صفحات ۵۳۱-۵۴۰
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عنوان انگلیسی Association Study of Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 and 2 Genes in Iranian Women with Preeclampsia
چکیده انگلیسی مقاله Abstract Background: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of ERAP1 and 2 genes polymorphism with Iranian preeclamptic women. Methods: In this case-control study, 148 preeclamptic and 133 pregnant women were selected from the Kosar Hospital, Qazvin, Iran, during 2013-2015. In order to genotype the subjects for rs28096, rs30187, rs26653, rs3734016, rs34750 and rs2549782, rs17408150 for ERAP1 and 2 genes, respectively, Real-Time PCR allelic discrimination approach was exploited. Results: Neither allelic nor genotype frequencies of all seven polymorphisms were significantly different between two groups. Though, ACGACTT and GTCAGGA haplotypes were related with decreased (P=0.0079, OR=0.559, 95% CI: 0.363-0.861 and P=0.02, OR=0.417, 95% CI: 0.194-0.896, respectively), but ACGACGT and GTGACTT haplotypes were associated with an increased (P=0.00082, OR=3.657, 95% CI: 1.630-8.206 and P=0.02, OR=2.401, 95% CI: 1.119-5.151, respectively) risk of preeclampsia. Moreover, some positions were detected to be in linkage disequilibrium. Conclusion: Ongoing investigation resulted differently from before performed studies considering the role of ERAP1 and ERAP2 gene polymorphisms in predisposing women to preeclampsia, emphasizing on the genetic structure differences among various racial populations.  
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نویسندگان مقاله | Hamid DARGAHI
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Hossein NICKNAM
1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Mahroo MIRAHMADIAN
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mahdi MAHMOUDI
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Saeed ASLANI
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Maryam SADROSADAT
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Robabeh GHODSSI-GHASSEMABADI
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Ali Akbar AMIRZARGAR
1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/16537
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354014.pdf
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