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Iranian Journal of Parasitology، جلد ۱۲، شماره ۴، صفحات ۶۲۲-۶۳۱
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عنوان انگلیسی Antileishmanial Activity of Lavandula angustifolia and Rosmarinus Officinalis Essential Oils and Nano-emulsions on Leishmania major (MRHO/IR/75/ER)
چکیده انگلیسی مقاله Background: The aim of present study was to evaluate antileishmanial effects of Lavandula angustifolia (L. angustifolia) and Rosmarinus officinalis (R. officinalis) medicinal plants essential oils and nano-emulsions on Leishmania major (L. major). Methods: The present study was performed in Leishmaniasis Reference Lab at Mazandaran University of Medical Sciences, Iran during 2016-2017. The IC50 values were calculated in both the promastigote and amastigote stages in J774 macrophage in comparison with meglumine antimoniate (MA) as positive control. In addition, cytotoxicity effects of essential oils and nano-emulsions prepared from both plants against macrophages were evaluated. Results: Both essential oil and nano-emulsion of Lavander and Rosemary showed anti-leishmania activity on promastigote with IC50=0.11 μl/mL, IC50=0.26 μl/mL, and IC50=0.08 μl/mL respectively. Moreover, during amastigote assay, Lavander and Rosemary essential oils and nano-emulsion were effective at least in concentration of 0.12 μl/mL and 0.06 µl/mL (P=0.0001) respectively, on mean infected macrophages (MIR) and amastigotes in macrophages (P=0.0001). Additionally, cytotoxicity assay against macrophage revealed no toxicity on the host cells at IC50 concentrations. Conclusion: The nano-emulsions of both plants were more effective than essential oil in both MIR and amastigote. However, in comparison with MA, the Lavander essential oil is more effective in reducing MIR. Rosemary nano-emulsion reduced MIR significantly more than MA in concentration of 0.25 μl/mL (P< 0.001). Further investigations are recommended to evaluate the effect of these medicinal plants in murine models.
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نویسندگان مقاله | Azar SHOKRI
Students Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran&#xD; Molecular and Cell Biology Research Center, Dept. of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Majid SAEEDI
Dept. of Pharmaceutics, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Mahdi FAKHAR
Molecular and Cell Biology Research Center, Dept. of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Katayoun MORTEZA-SEMNANI
Dept. of Medicinal Chemistry, School of Pharmacy, Mazandaran University of Medical, Sciences, Sari, Iran


| Masoud KEIGHOBADI
Students Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Saeed HOSSEINI TESHNIZI
Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Hamid Reza KELIDARI
Dept. of Pharmaceutics, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Siamak SADJADI
Students Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1937
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