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Iranian Journal of Parasitology، جلد ۱۳، شماره ۴، صفحات ۵۷۷-۵۸۶
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عنوان انگلیسی Molecular Characterization of Echinococcus granulosus Sensu Lato from Livestock in North Khorasan Province, Iran
چکیده انگلیسی مقاله Background: Echinococcus granulosus is one the most important zoonotic disease which is endemic in worldwide. Molecular method has allowed discrimination of different genotypes (G1-G10), providing new approach in development of prevention and control program of hydatid cyst. This study was conducted to identify the genotypes of E. granulosus from domestic animals in nine districts of North Khorasan Province using the mitochondrial cox1 gene sequence. Methods: Overall, 122 hydatid cyst were collected during 2016-2017 from sheep (n=43) and cattle (n=79). DNA was extracted from protoscoleces and germinal layers and amplified by PCR. Phylogenetic analysis was also performed by analyzing the complete nucleotide sequences of mitochondrial cytochrome C oxidase subunit 1 (cox1) of E. granulosus genotypes from various locations. Results: Sequencing of the amplified products revealed the presence of G1 as dominant genotype, G3 and Echinococcus canadenesis in one isolate each. Altogether, 9 haplotypes were detected based on cox1 gene. Haplotype 3 was the common variant that found in 58 including 42 cattle and 16 sheep. Conclusion: This study provided knowledge on the identity of E. granulosus cysts collected from sheep and cattle in North Khorasan Province. Furthermore, these results showed the potentials of sheep as a main source of infection to humans, contributing the transmission and maintain of hydatid cyst in this region.
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نویسندگان مقاله | Mitra SALEHI
Dept. of Parasitology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran and Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran andVector-Borne Diseases Research Center, North Khorasan University of Medical & Laboratory of North Khorasan Veterinary Head office, Bojnurd, Iran


| Saeed YAGHFOORI
Dept. of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


| Pejman BAHARI
Vector-Borne Diseases Research Center, North Khorasan University of Medical & Laboratory of North Khorasan Veterinary Head office, Bojnurd, Iran


| Mohsen SEYEDABADI
Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran and Vector-Borne Diseases Research Center, North Khorasan University of Medical & Laboratory of North Khorasan Veterinary Head office, Bojnurd, Iran


| Sima PARANDE SHIRVAN
Vector-Borne Diseases Research Center, North Khorasan University of Medical & Laboratory of North Khorasan Veterinary Head office, Bojnurd, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/2406
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-1353760.pdf
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