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Iranian Journal of Parasitology، جلد ۱۴، شماره ۱، صفحات ۵۹-۶۷
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عنوان انگلیسی New Method of Production and Characterization of Haemozo-in and Β-Haemozoin from Meccus longipennis
چکیده انگلیسی مقاله Background: Understanding the significance of hemozoin (Hz) in the process through which Plasmodium is released from the heme group in the food vacuole during hemoglobin degradation, will allow the development of more effective drugs against malaria. Therefore, the development of methodologies to obtain Hz synthetically will facilitate an in vitro evaluation of new anti-malarial drugs. Methods: We present a methodology with good results to obtain Hz from fecal material of blood-sucking insects Meccus longipennis. The preparation of biological cultures of the parasite (Plasmodium) transmitter of the disease is not necessary. Results: The hemozoin molecule and its dimer were obtained using the method described and it was possible to validate a comparison with the positive and negative controls using different analytical techniques. Conclusion: The proposed method allows obtaining hemozoin and its dimer demonstrating equivalence with positive controls that demonstrate that the present procedure may be an alternative for the evaluation of antimalarial drugs.
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نویسندگان مقاله | Liliana GONZÁLEZ-LINARES
Department of Medicine, School of Biological and Health Sciences, Autonomous University of Hidalgo State, Hidalgo, México


| Víctor Esteban REYES-CRUZ
Department of Materials and Earth Sciences, School of Engineering and Basic Sciences, Autonomous University of Hidalgo State, Hidalgo, México


| María Aurora VELOZ-RODRÍGUEZ
Department of Materials and Earth Sciences, School of Engineering and Basic Sciences, Autonomous University of Hidalgo State, Hidalgo, México


| Gustavo URBANO-REYES
Department of Materials and Earth Sciences, School of Engineering and Basic Sciences, Autonomous University of Hidalgo State, Hidalgo, México


| José Luis IMBERT-PALAFOX
Department of Medicine, School of Biological and Health Sciences, Autonomous University of Hidalgo State, Hidalgo, México


| José Angel COBOS-MURCIA
Department of Materials and Earth Sciences, School of Engineering and Basic Sciences, Autonomous University of Hidalgo State, Hidalgo, México Mexican National Council for Science and Technology, México City, México
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1804
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-1353730.pdf
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