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Archives of Anesthesiology and Critical Care، جلد ۱، شماره ۱، صفحات ۱۸-۲۰
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عنوان انگلیسی Effects of Oral Tizanidine Premedication on Pain and Hemodynamic Responses after Spinal Needle Skin Puncture
چکیده انگلیسی مقاله Background: Although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. In this study we evaluated the effects of oral Tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses. Methods : In this double blind randomized clinical trial, 52 patients who were scheduled for elective surgeries under spinal anesthesia were recruited. They were randomly allocated in 2 groups of case and control. In the case group 4mg oral Tizanidine was administered to patients one hour before surgery while control group received placebo Heart rate, systolic and diastolic blood pressure were recorded exactly before spinal needle puncture and 1,3 and 5 minutes after spinal anesthesia. Results: The mean average of pain score was significantly lower in case group (p< 0.001). Also hemodynamic variables, in terms of heart rate and diastolic blood pressure, were statistically different between two groups (p=0.04 and p=0.02); however, the difference between systolic blood pressure was not significant between two groups. Conclusion : Premedication with 4mg oral Tizanidine produced stability in blood pressure and heart rate during surgery and reduced pain intensity caused by needle puncture.
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نویسندگان مقاله گیتا شعیبی | gita shoeibi
department of anesthesiology and critical care medicine, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سوسن سلطانی محمدی | sussan soltani mohammadi
department of anesthesiology and critical care medicine, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آیلار آهنگری | ailar ahangari
department of anesthesiology and critical care medicine, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شقایق مرعشی | shaqayeq marashi
department of anesthesiology and critical care medicine, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی برجی | ali borji
department of anesthesiology and critical care medicine, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیر عباس یاقوتی | amir abbas yaghooti
department of anesthesiology and critical care medicine, bahrami hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://aacc.tums.ac.ir/index.php/aacc/article/view/18
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