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Archives of Breast Cancer، جلد ۱، شماره ۳، صفحات ۹۵-۹۸
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عنوان انگلیسی Cytotoxic Activity of Selected Iranian Traditional Medicinal Plants on Colon, Colorectal and Breast Cancer Cell Lines
چکیده انگلیسی مقاله Background: Many natural products from plants have been recognized to exert anticancer activity. In this study, ethanolic extracts of selected medicinal herbs from Iranian flora including Alyssum homolocarpum Fisch. (from seeds), Urtica dioica L. (from aerial parts), Cichorium intybus L. (from roots) and Solanum nigrum L. (from fruits), were evaluated for their cytotoxic effect on different cell lines. Methods: Cytotoxic effect of these extracts was studied on three different cancer cell lines; colon carcinoma (HT-29), colorectal adenocarcinoma (Caco-2) and breast ductal carcinoma (T47D). In addition, Swiss mouse embryo fibroblasts (NIH 3T3) were used as normal nonmalignant cells. MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was utilized for calculating the cytotoxicity of extracts on cell lines. Results: Results showed the potent cytotoxic activity of U. dioica ethanolic extract against T47D cell line with IC50 value of 46.14±4.55 µg/ml. Other extracts showed poor activity with IC50>100 µg/ml. Conclusions: Cytotoxic activity recorded in the present study revealed high potential antiproliferative activity of U. dioica ethanolic extract against T47D cell line. The real IC50 values of this extract may be considerably lower than the IC50 measured in our study if its pharmacological active compounds become pure. The results emphasize the importance of studies on U. dioica ethanolic extract to characterize potential components as cytotoxic natural medicines.
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نویسندگان مقاله لیلا محمد تقی زاده کاشانی | leila mohammad taghizadeh kashani
department of traditional medicine, medicinal plants research center of barij, kashan, iran


مریم مجدزاده | maryam majdzadeh
department of toxicology amp;amp; pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهناز خانوی | mahnaz khanavi
department of pharmacognosy, faculty of pharmacy and medicinal plants research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محسن تقی زاده | mohsen taghizadeh
research center for biochemistry amp;amp; nutrition in metabolic disease, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

نرگس ساداتی | narges sadati
department of traditional pharmacy, faculty of traditional medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نیلوفر کهکشانی | niloofar kahkeshani
department of pharmacognosy, faculty of pharmacy and medicinal plants research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ملودی وطن خواه | melodi vatankhah
department of biology, faculty of science, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سید ناصر استاد | seyed nasser ostad
department of toxicology amp;amp; pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.archbreastcancer.com/index.php/abc/article/view/21
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زبان مقاله منتشر شده en
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