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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۳، صفحات ۱۶۲-۱۶۲
عنوان فارسی ?P۱۳۸: Are Depression and Anxiety Affected by Adenosine A۲A Receptors
چکیده فارسی مقاله لطفأ به لینک انگلیسی مراجعه شود.
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عنوان انگلیسی P138: Are Depression and Anxiety Affected by Adenosine A2A Receptors?
چکیده انگلیسی مقاله Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP production. These receptors are distributed in various areas of the central nervous system. A2AR is highly expressed in the olfactory bulb, caudate putamen, nucleus accumbens, and tuberculum olfactorium. The function of several receptors such as dopamine D2 receptor (D2R) is influenced by activation of adenosine A2A receptor. Three distinct dopamine projection pathways are formed from the substantia nigra–ventral tegmental area complex. Mesocortical pathway and mesolimbic pathway are known as first and second pathways. Axons project to the striatum, described nigrostriatal pathway known as third pathway. This pathway completes the neural circuits of the basal ganglia responsible for motor control, although recent document also points to a very important role in the motor changes associated with severe depression. Adenosine A2A receptor and D2R are co-localized in the dorsal and ventral striatum and are mutual inhibitors. On one hand, A2AR–D2R heteromers are formed and, when the A2AR is activated, conformational changes are transferred to the D2R. This ultimate to a reduction in D2R recognition and signaling on the other hand, D2R activation inhibits cAMP mediated-effects of A2AR by inhibiting adenylyl-cyclase. Finally, recant study showed that A2AR overexpression is associated with depression, which may describe the depressive signs seen in aging, chronic stress, and Alzheimer’s disease. We hypothesized that changes in expression of A2AR in nigrostriatal system may contribute in creation of depression with motor disorders.
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نویسندگان مقاله شاهین محمد صادقی | shahin mohammad sadeghi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی کاظمی | hadi kazemi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. pediatric department, shahed university, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

ذبیح اله خاکسار | zabihollah khaksar
histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

امین افصحی | amin afsahi
health office expert in tehran municipality-district 20, tehran, iran.
نشانی اینترنتی http://www.shefayekhatam.ir/browse.php?a_code=A-10-24-192&slc_lang=en&sid=fa
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده روانشناسی
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