|
|
International Journal of Pediatrics، جلد ۲، شماره ۲.۳، صفحات ۱۷-۱۷
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Comparative analysis of the Gene expression profile of Chemokine Receptors between Adipose-derived and Bone marrow-derived Mesenchymal Stem Cells |
|
| چکیده انگلیسی مقاله |
Introduction: Mesenchymal stem cells (MSCs) hold great promise in the field of regenerative medicine.Although originally isolated from bone marrow, MSCs have since been obtained from a variety of adult and neonatal tissues including the adipose tissue. Stemness and multipotential features of Mesenchymal Stem Cells (MSC) has been highlighted in many studies but there are many dark aspects in exclusive capabilities of MSC derived from different sources. Regarding adipose-derived MSCs, Ad-MSCs, and bone marrow- derived MSC, BM-MSCs has been introduced and applicable in clinics, we designed a small molecule induction based approach for evaluation of gene expression response between these cells. Materials and Methods: A panel of MSC specific genes encoding CXCR4, CXCR6, CX3CR1 and CCR1 has been comparatively analyzed between Ad-MSCs and BM-MSCs by Real-Time PCR, in response to hypoxia- mimicking agents CoCl2, DFX and VPA. Results: Our results showed CXCR4 expression dramatically increased following DFX and VPA treatment in Ad-MSC but decreased in BM-MSCs, over expression of CCR1 was detected only in BM-MSCs but CXCR6 and CX3CR1didn't show any detectable expression between these kinds of MSCs. Conclusion: We speculate that differential expression profile of CXCR4 and CCR1 related to different capabilities of BM-MSCs and Ad-MSCs and further investigations necessary to determine which gene networks play the key roles in MSCs derived from different sources and these findings translated from bench to bed in novel cell therapies. Keywords: Adipose-derived MSCs, Bone marrow-derived MSCs, Chemokine Receptors, Gene expression. |
|
| کلیدواژه‌های انگلیسی مقاله |
Oral Presentation |
|
| نویسندگان مقاله |
حمیدرضا بیدخوری | hamid reza bidkhori
stem cells and regenerative medicine research department, acecr-khorasan razavi branch, mashhad, iran.
معین فرشچیان | moien farshchian
department of biology, ferdowsi university of mashhad, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
آسیه حیرانی طبسی | asieh heirani tabasi
stem cells and regenerative medicine research department, acecr-khorasan razavi branch, mashhad, iran.
حجت نادری مشکین | hojjat naderi meshkin
stem cells and regenerative medicine research department, acecr-khorasan razavi branch, mashhad, iran.
مهتاب دست پاک | mahtab dastpak
department of biology, ferdowsi university of mashhad, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
نغمه احمدیان کیا | naghmeh ahmadian kia
shahrood university of medical sciences, shahrood, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شاهرود (Shahrood university of medical sciences)
احمدرضا بهرامی | ahmad reza bahrami
department of biology, ferdowsi university of mashhad, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
مریم m متین | maryam m matin
department of biology, ferdowsi university of mashhad, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
|
|
| نشانی اینترنتی |
http://ijp.mums.ac.ir/article_2666.html |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|