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Journal of Medical Bacteriology، جلد ۴، شماره ۵, ۶، صفحات ۲۴-۳۰
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عنوان انگلیسی Anti-CagA IgG Antibody is Independent from Helicobacter pylori vacA and cagA Genotypes
چکیده انگلیسی مقاله Background: Helicobacter pylori strains have two classical virulence genes, the cytotoxinassociated A ( cagA ) gene and the vacuolating cytotoxin A ( vacA ) gene, which are located in the cag pathogenicity island ( cag PAI). Serum immunoglobulin G (IgG) antibodies to H. pylori , especially, the CagA antigen may be a reliable marker for selection of dyspeptic patients for upper endoscopy. Methods : Serum sample of 129 dyspeptic patients with positive H. pylori , were tested for serum IgG Anti-CagA antibody by ELISA. The presence of the cagA and vacA genotypes were determined using polymerase chain reaction (PCR) on biopsy samples taken via endoscopy. Results : Positive serum IgG anti-CagA antibodies in patients with cagA + /vacA + and cagA + /vacA - genotypes were 22/23 (95.6%) and 18/19 (94.7%), respectively. In addition, serum IgG anti-CagA antibodies in patients with cagA - /vacA + and cagA - /vacA - genotypes were 22/47 (46.8%) and 33/40 (82.5%), respectively. Conclusions : It can be concluded that the serum IgG anti-CagA antibody alone could select patients with dyspepsia following upper endoscopy. The assessment of vacuolating cytotoxin activity of H. Pylori is, therefore, not required, even when vacA gene is positive. This hypothesis needs to be studied in a large number of patients with dyspepsia.
کلیدواژه‌های انگلیسی مقاله Dyspepsi, cagA, vacA
نویسندگان مقاله هاشم فخر یاسری | hashem fakhre yaseri
1 gastroenterology, research center for gastroenterology and liver disease, firoozgar hospital, iran university of medical sciences, tehran, iran. 2 department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مهدی حسینی شکرابی | mehdi shekaraby
immunology research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حمیدرضا | hamid reza baradaran
department of epidemiology, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید کامران سلطانی عربشاهی | seyed kamran soltani arabshahi
department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/113
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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