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Asia Pacific Journal of Medical Toxicology، جلد ۳، شماره Supplement ۱، صفحات ۱۱-۱۱
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عنوان انگلیسی Antioxidant Effect of Ardeh and Honey Combination on Ethanol-induced Oxidative stress in Liver and Kidney of Rats
چکیده انگلیسی مقاله Background: The pathogenesis of ethanol in the liver and kidney is associated with an increase in free radicals and oxidative stress that leads to structural and functional abnormalities in these vital organs. Methods: Forty-eight male wistar rats were placed in eight groups and were treated as follows: control group (normal saline), group of ethanol (4 g/ kg), three doses of Ardeh and honey combination (1, 2 and 5 g/ kg body weight), and the three groups received three doses of Ardeh and honey combination with ethanol (the same three doses of combinations along with 4 g/ kg ethanol). All treatments were performed once daily for 60 consecutive days with method of stomach gavages. Serum, liver and kidney tissue samples were obtained in order to assess serum components, tissue antioxidant enzyme activities, and the level of thiobarbituric acid reactive substances (TBARS). Results: Hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes in the ethanol group significantly decreased compared with the control group, while the Ardeh and honey combination (5 g) could only significantly increased glutathione peroxidase activity. Renal GPx activity in ethanol consumption significantly increased compared to controls. GPx activity in Ardeh and honey combination and alcohol (5 g, 4 g) were significantly reduced compared to ethanol group. In the present study, the amount of TBARS which represents the rate of lipid peroxidation, in liver of ethanol group compared with the control group showed a significant increase (P< 0.05). Conclusion: Ardeh and honey combination as a pre-treatment, protect liver and kidney against oxidative damage induced by ethanol.
کلیدواژه‌های انگلیسی مقاله Antioxidants, Ethanol, kidney, Liver, Oxidative stress
نویسندگان مقاله محمود ابراهیمی | mahmoud ebrahimi
atherosclerosis research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محسن ابراهیمی | mohsen ebrahimi
department of emergency medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ابوالقاسم الهیاری | abolghasem allahyari
department of clinical hematology-oncology, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مصطفی قلی زاده | mostafa gholizadeh
department of chemistry, faculty of basic sciences, ferdowsi university, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

محمد کریمی | mohammad karimi
imam reza hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا کاظمی | mohammad reza kazemi
imam reza teaching hospital medical center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مرضیه کریمی | marziyeh karimi
faculty of nursing, islamic azad university, sabzevar branch, sabzevar, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://apjmt.mums.ac.ir/article_2886.html
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