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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۱، صفحات ۴۴-۵۳
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عنوان انگلیسی Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial
چکیده انگلیسی مقاله Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. To evaluate the extract safety, serum SGOT, SGPT and creatinine levels were tested; also, the patients were requested to report any adverse effects.   Results: FG, 2hPPG, HbA1c, TC, LDL-C, triglyceride and systolic and diastolic blood pressures were decreased, whereas HDL-C was increased significantly in the extract group compared to those of the placebo group at the endpoint (for all cases, p< 0.05). The extract did not significantly influence other parameters and no adverse effects were reported. Conclusion: V. arctostaphylosleaf hydro-alcoholic extract as an adjunct to the conventional drugs has additional antihypertensive as well as anti-dyslipidemic and anti-hyperglycemic effects in hypertensive hyperlipidemic type 2 diabetic patients. Besides, the extract lacks hepatic, renal and patient-reported adverse effects.  
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نویسندگان مقاله | Reza Mohtashami
Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Hasan Fallah huseini
Medicinal Plants Research Center, Institute of Medicinal Plants,ACECR, Karaj, Iran.


| Farzaneh Nabati
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.


| Reza Hajiaghaee
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.


| Saeed Kianbakht
Institute of Medicinal Plants (ACECR)
نشانی اینترنتی http://ajp.mums.ac.ir/article_11588.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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