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Bulletin of Emergency and Trauma، جلد ۴، شماره ۳ JUL، صفحات ۱۳۴-۱۴۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-::union:: Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial |
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| چکیده انگلیسی مقاله |
Objective: To determine the effects of platelet rich plasma PRP on healing rates of long bone non-::union:: fracture. Method: This was a randomized double-blind placebo controlled clinical trial being performed in a 12-month period. We included 75 adult (>18 years) patients suffering from long bone (Femur, Tibia, Humerus and Ulna) non-::union:: fracture who were randomly assigned to receive 5mL PRP (n=37) or 5mL normal saline as placebo (n=38) in the site of fracture after intramedullary nailing or open reduction and internal fixation (ORIF) along with autologous bone graft. Patients were followed each 45 days till 9 months and were evaluated both clinically and radiologically in each visit. The healing rate, failure rate, incidence of infection, mal-::union:: and limb shortening were recorded and compared between groups after 9 months of follow-up. Results: The healing rate was significantly higher in PRP group compared to placebo (81.1% vs. 55.3%; p=0.025 ). The limb shortening was significantly higher in those who received placebo (2.61±1.5 vs. 1.88±1.2mm; p=0.030 ). Injection of PRP was also associated with lower pain scores ( p=0.003 ) and shorter healing duration ( p=0.046 ). The surgical site infection ( p=0.262 ) and mal-::union:: rate ( p=0.736 ) were comparable between groups. Conclusion: Application of PRP along with autologous bone graft in the site of non-::union:: of long bone after intramedullary nailing or ORIF results in higher cure rate, shorter healing duration, lower limb shortening and less postoperative pain. Higher infection rate might be a complication of PRP application. Keywords: Non-::union::; Long bone Fracture; Platelet rich plasma (PRP); Intramedullary nailing; Open reduction and internal fixation (ORIF). Clinical Trial Registry: This trial is registered with the Iranian Clinical Trials Registry (IRCT201208262445N1; www.irct.ir ). |
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| نویسندگان مقاله |
فریبرز غفارپسند | fariborz ghaffarpasand
shiraz university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
مصطفی شاهرضایی | mostafa shahrezaei
aja university of medical sciences
مریم دهقان خلیلی | maryam dehghankhalili
shiraz university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
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| نشانی اینترنتی |
http://www.beat-journal.com/BEATJournal/index.php/BEAT/article/view/254 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original |
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