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Journal of Dentomaxillofacil Radiology, Pathology and Surgery، جلد ۴، شماره ۲، صفحات ۳۰-۳۴
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عنوان انگلیسی Fascin Expression in Oral Squamous Cell Carcinoma using an Immunohistochemical Technique
چکیده انگلیسی مقاله Introdouction: Oral squamous cell carcinoma (OSCC), the most common form of oral cancer, requires early diagnosis and suitable treatments. Fascin is a protein involved in cell adhesion and is increased in expression in certain types of carcinomas. The present study was conducted to assess fascin expression in OSCC using an immunohistochemical technique. Materials and methods: In the present retrospective study, 25 paraffin blocks of OSCC samples were selected and immunohistochemically stained for detection of fascin expression. Fascin expression rate was calculated as the sum of stained cells (scores from 0 to 4) and staining intensity (scores from 0 to 3). Results: Samples collected from 18 men and 7 women, with a mean age of 57.42 years, were assessed, which showed that the most usually affected sites were the gingiva and the tongue. Fascin expression was positive for all the samples and had the highest possible score (24 cases with score 7 and 1 case with score 6). Fascin expression level was not found to have a significant relationship with age, gender, and tumor location (P > 0.05). The data were analyzed using SPSS statistical software (18) via chi-square analysis, independent T test and One way Anova p < 0.05 was considered significant. Conclusion: Irrespective of the clinical parameters, fascin expression is possibly involved in the etiology of OSCC target therapy medicines can therefore be used in the future to treat this malignancy.
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نویسندگان مقاله سعیده عطارباشی مقدم | saede atarbashi moghadam
department of oral and maxillofacial pathology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

ژاله محسنی فر | zhale mohsenifar
department of pathology, taleghani eِducational hospital of shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علی لطفی | ali lotfi
department of oral and maxillofacial pathology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

لاله عباسی | lale abasi


سیده سارا باقری | seyedeh sara bagheri
department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

نشانی اینترنتی http://3dj.gums.ac.ir/browse.php?a_code=A-10-1-78&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pathology
نوع مقاله منتشر شده پژوهشی
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