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World Journal of Plastic Surgery، جلد ۱، شماره ۲، صفحات ۶۴-۷۰
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عنوان انگلیسی The Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model
چکیده انگلیسی مقاله BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal random pattern skin flap was elevated. To prevent the graft effect, a sterile sheet was put under the flap. No pharmacological agent was administered for the control group. In group 2, single subcutaneous dose of enoxaparin (3.2 mg/kg) was immediately administrated after surgery. In group 3, clopidogrel (25 mg/kg) was given orally for 7 days. In group 4, both enoxaparin and clopidogrel were administrated. The rats were evaluated on post-operative day 7 for viable and necrotic portions of flaps. RESULTS The mean and SD of necrosis was 17.79+2.5 cm in the control group, 16.20±3.1 cm in low-molecular weight heparin, 15.25+3.8 cm in combined therapy group and 13.69+2.7 cm in clopidogrel group. Clopidogrel was the only pharmaceutical agent that produced a significant increase in the flap survival area. CONCLUSION Clopidogrel may be an effective pharmaceutical agent that significantly increases viability of random skin flaps in rats, but low-molecular weight heparin and their combination did not have any significant beneficial effects.
کلیدواژه‌های انگلیسی مقاله Enoxaparin, Clopidogrel, Survival, Skin flap, Rat
نویسندگان مقاله محمد جواد فاطمی | mohammad javad fatemi
associate professor of department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کمال s فروتن | kamal s forootan
associate professor of department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید ضیاالدین s جلالی | seyed ziaaddin s jalali
plastic surgeon, vali asr police hospital, tehran, iran.


سید جابر موسوی | seyed jaber mousavi
department of community medicine, burn research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میرسپهر پدرام | mir sepehr pedram
veterinary surgeon, school of veterinary medicine, tehran university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://www.wjps.ir/browse.php?a_code=A-10-35-2&slc_lang=en&sid=en
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