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Avicenna Journal of Phytomedicine، جلد ۱، شماره ۱، صفحات ۷-۱۳
عنوان فارسی
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عنوان انگلیسی Zataria multiflora Boiss inhibits muscarinic receptors of incubated tracheal smooth muscle with propranolol
چکیده انگلیسی مقاله Objective(s): In the present study, the effect of tissue incubation with propranolol on functional antagonism of Zataria multiflora Boiss (Z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined. Materials and Methods: The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine, and saline on muscarinic receptors were tested on incubated tracheal smooth muscle with propranolol (n=5). Results: The EC50 of all concentration of the extract and atropine was significantly higher than that of saline. There was parallel right ward shift in concentration response curves obtained in the presence of all concentrations of the extract. There was not any significant difference in the maximum response and slope obtained in the presence of different concentrations of extract compared to saline. There was significant positive correlation between the concentrations and the values of EC50 (p< 0.001). The value of (CR-1) obtained in the presence of highest concentration of the extract was significantly higher than that of atropine (p< 0.05). Conclusion: These results indicated that functional antagonism of Z. multiflora at muscarinic receptors of tracheal smooth muscle was mainly due to b-adrenoceptor stimulatory effect of plant.
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نویسندگان مقاله زهرا جعفری | zahra jafari
department of physiology and pharmaceutical research centre, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد حسین بسکابادی | mohammad hossein boskabady
department of physiology and pharmaceutical research centre, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ایران پورابولی | iran pouraboli
department of biology, school of sciences, shahid bahonar university, kerman, i. r. iran

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

بهشته بابازاده | beheshteh babazade
department of physiology and pharmaceutical research centre, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_115.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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