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Avicenna Journal of Phytomedicine، جلد ۲، شماره ۲، صفحات ۹۰-۹۶
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عنوان انگلیسی The effect of red grape juice and exercise, and their combination on parkinson’s disease in rats
چکیده انگلیسی مقاله Objective: Parkinson's disease (PD) is one of the most common neurodegenerative disorders which is characterized by tremor, rigidity, bradykinesia and postural disturbances. Studies indicate that grape juice and exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of red grape juice (GJ) together with treadmill running on animal model of PD. Materials and Methods: 30 male Wistar rats were divided randomly into Sham, PD, PD treated with GJ (PD-GJ), PD treated with exercise (PD-Ex), and PD treated with GJ associated with exercise (PD-GJ-Ex) groups with six rats in each. In order to obtain the PD model, 6-OHDA was infused into left substantia nigra pars compacta. In order to prove that the lesions are created and to estimate their extent, apomorphine was administered (i.p.) and total number of induced rotations was recorded during 60 minutes. Exercise was applied by treadmill and GJ was added into drinking water for 30 days and rotations test was performed again. Results: Our results indicate that there was a significant difference in number of rotations between PD and Sham groups (p< 0.05). At the end of experiment, number of rotations decreased significantly in both PD-GJ and PD-GJ-Ex groups (p< 0.05). Exercise alone increased the number of rotations non- significantly. Conclusion: Grape juice reduced rotations probably via the antioxidant agents. 
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نویسندگان مقاله فاطمه اشراقی جزی | fatemeh eshraghi jazi
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حجت اله علایی | hojjatallah alaei
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حمید عزیزی ملک آبادی | hamid azizi malekabadi
islamic azad university, khorasgan branch, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهین غروی نایینی | mahin gharavi naini
department of physiology, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی اصغر پیله وریان | aliasghar pilehvarian
isfahan payame noor university, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

زهرا ciahmard | zahra ciahmard
isfahan payame noor university, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_39.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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