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Avicenna Journal of Phytomedicine، جلد ۲، شماره ۳، صفحات ۱۶۲-۱۶۸
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عنوان انگلیسی Neuro-pharmacological effects of Crinum zeylanicum in mice
چکیده انگلیسی مقاله Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p< 0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p< 0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p< 0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod. Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
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نویسندگان مقاله adeniyi یحیی تیجانی | adeniyi yahaya tijani
department of pharmacology and toxicology, national institute for pharmaceutical research and development idu industrial area, abuja, nigeria


oluwakanyinsola adeola salawu | oluwakanyinsola adeola salawu
department of pharmacology and toxicology, national institute for pharmaceutical research and development idu industrial area, abuja, nigeria


گودرزی نیا luck jaiyeoba | good luck jaiyeoba
department of pharmacology and toxicology, national institute for pharmaceutical research and development idu industrial area, abuja, nigeria


یوسف akponso anuka | joseph akponso anuka
department of pharmacology and therapeutics, faculty of pharmaceutical sciences, ahmadu bello university, zaria, nigeria


isah marte حسینی | isah marte hussaini
department of pharmacology and therapeutics, faculty of pharmaceutical sciences, ahmadu bello university, zaria, nigeria
نشانی اینترنتی http://ajp.mums.ac.ir/article_104.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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