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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۱، صفحات ۴۳-۵۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone
چکیده انگلیسی مقاله Objectives: The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice. Materials and Methods: Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. Control group: received saline 0.1 ml/mouse/day orally for 30 days. Royal Jelly group (RJ): received royal jelly at dose of 100 mg/kg daily for 30 days orally. Oxymetholone group: the received Oxymetholone (OX) at dose of 5 mg/kg daily for 30 days orally. Royal Jelly+Oxymetholone group: received royal jelly at dose of 100 mg/kg/day orally concomitant with OX administration. Sperm count, sperm motility, viability, maturity, and DNA integrity were analyzed. Furthermore, serum testosterone and MDA concentrations were determined. Results: In Oxymetholone group, sperm count, motility as well as testosterone concentration reduced significantly (p< 0.05), while significant (p< 0.05) increases in immature sperm, sperm with DNA damaged, and MDA concentration were announced in Oxymetholone group in comparison with control group and Royal Jelly+Oxymetholone group. RJ caused partially amelioration in all of the above- mentioned parameters in Royal Jelly+Oxymetholone group. Conclusion: In conclusion, RJ may be used in combination with OX to improve OX-induced oxidative stress and male infertility.
کلیدواژه‌های انگلیسی مقاله Mice, Oxymetholone, Royal jelly, Sperm
نویسندگان مقاله انسیه زحمتکش | ensieh zahmatkesh
department of histology and embryology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

غلامرضا نجفی | gholamreza najafi
department of anatomy and embryology, faculty of veterinary medicine, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

وحید نجاتی | vahid nejati
department of histology and embryology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

رضا حیدری | reza heidari
department of biochemistry, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_896.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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