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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۳، صفحات ۱۹۱-۱۹۹
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عنوان انگلیسی Chemical composition of essential oil and anti trichomonas activity of leaf, stem, and flower of Rheum ribes L. extracts
چکیده انگلیسی مقاله Objectives: Trichomoniasis is one of the most common sexually transmitted diseases in humans and is caused by the protozoan Trichomonas vaginalis. Nowadays, increasing resistance to drugs such as metronidazole resulted in many problem, so new effective remedies are needed. In this study, we evaluate constituents of essential oil and anti-trichomonas activity of Rheum ribes. Materials and Methods: The essential oil from Rheum ribes L.flower growing wild in Iran was analyzed by GC/MS. The parasites were treated with different extract and fractions of the flower, stem, and leave of the plant. Anti-trichomonas activity was evaluated using an in vitro assay. Results: In all, 19 compounds were identified; palmitic acid [27.08%], n-eicosane [9.9%], n-tetracosane [7.34%], linoleic acid [6.56%], and ethyl linoleate [4.76%] were the main components of the oil. Rheum ribes extracts and fractions concentration dependently inhibited the ability of parasites to growth. This was associated with polarity of solvent used for fractionation and plant parts used for extraction. Conclusion: Findings demonstrate the potential of Rheum ribes extracts as an anti-trichomonas agent for human use. Further studies are required to evaluate its toxicity and safety.
کلیدواژه‌های انگلیسی مقاله Essential oil, Rheum ribes, Trichomonas vaginalis
نویسندگان مقاله فروغ ناعمی | forough naemi
department of pharmacognosy, faculty of pharmacy, isfahan university of medical sciences, isfahan, ir iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

غلامرضا اصغری | gholamreza asghari
isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, i. r iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حسین یوسفی | hossein yousofi
department of parasitology, faculty of medicine, isfahan university of medical sciences, isfahan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حسینعلی یوسفی | hossein ali yousefi
department of parasitology, faculty of medicine, isfahan university of medical sciences, isfahan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_1968.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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