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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۳، صفحات ۱۶۰-۱۶۹
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عنوان انگلیسی Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin
چکیده انگلیسی مقاله Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett’s T3 multiple comparison test, and Dunnett’s t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon. Conclusions: This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted.
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نویسندگان مقاله tamègnon victorien dougnon | tamègnon victorien dougnon
laboratory of toxicology and environmental health, interfaculty center of formation and research in environment for the sustainable development, university of abomey-calavi uac , 01 po box 1463 cotonou, benin


honoré sourou bankolé | honoré sourou bankolé
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


جان رابرت klotoé | jean robert klotoé
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


maximin sènou | maximin sènou
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


lauris fah | lauris fah
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


hornel koudokpon | hornel koudokpon
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


casimir akpovi | casimir akpovi
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


tossou ژاک dougnon | tossou jacques dougnon
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


phyllis addo | phyllis addo
department of animal experimentation, noguchi memorial institute for medical research nmimr , university of ghana, po box lg 581 legon, ghana


frédéric loko | frédéric loko
laboratory of research in applied biology, polytechnic school of abomey-calavi, university of abomey-calavi, 01 po box 2009 cotonou, benin


مایکل boko | michel boko
laboratory of toxicology and environmental health, interfaculty center of formation and research in environment for the sustainable development, university of abomey-calavi uac , 01 po box 1463 cotonou, benin
نشانی اینترنتی http://ajp.mums.ac.ir/article_2208.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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