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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۳، صفحات ۱۴۴-۱۵۰
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عنوان انگلیسی The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits
چکیده انگلیسی مقاله Objective: This study was designed to investigate the effect of hydroalcoholic extract and essential oil of Heracleum persicum (Apiaceae) on lipid profile of male hyperlipidemic rabbits. Materials and Methods: Thirty rabbits were randomly divided into six groups of five each. One group received normal diet and the other groups fed with a high cholesterol (2% W/W) diet for 7 weeks. Vehicle, hydroalcoholic extract (500 and 1000 mg/kg), essential oil (200 ml/kg), and lovastatin (5 mg/kg) were administered orally to animals and their effects on lipid profile were evaluated. Results: Essential oil of H. perscum significantly (p< 0.05) lowered serum triglyceride level and increased HDL-cholesterol concentration. Moreover, hydroalcoholic extract (1000 mg/kg), essential oil (200 ml/kg), and lovastatin significantly (p< 0.01) reduced serum concentration of total cholesterol and LDL-cholesterol. Conclusion: These findings suggest that essential oil of the plant fruits may have some benefits in reducing cardiovascular risk factors.
کلیدواژه‌های انگلیسی مقاله Essential oil, Heracleum persicum, Hyperlipidemia
نویسندگان مقاله ولی اله حاج هاشمی | valiollah hajhashemi
department of pharmacology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

غلامرضا دشتی | gholamreza dashti
department of anatomy, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

salabali صابری | salabali saberi
department of pharmacology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پروین malekjamshidi | parvin malekjamshidi
department of anatomy, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_2274.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short communication
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