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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۵، صفحات ۳۳۷-۳۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes
چکیده انگلیسی مقاله Objective: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F.szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes. Materials and Methods: Human lymphocytes were incubated with H2O2 (0, 25, 50, 100, and 200 µM), galbanic acid (200 and 400 µM) and a combination of galbanic acid (200 and 400 µM) and H2O2 (25 µM) at 4 C for 30 minutes. Solvents of galbanic acid without H2O2 were used as negative controls. Results: The findings of this study demonstrated that H2O2 exposure leads to a significant concentration-dependent increase in DNA damage. Galbanic acid did not cause DNA damage compared with the control cells. Data showed that galbanic acid does not have a protective effect against H2O2-induced oxidative DNA damage in human lymphocytes. Conclusion: According to the results, it is concluded that the capability of F. szowitsiana in reducing reactive oxygen species and the anti-inflammatory property of its methanolic extract may be due to its other ingredients.
کلیدواژه‌های انگلیسی مقاله Comet assay, DNA damage, Galbanic acid, Ferula szowitsiana
نویسندگان مقاله کبری شیرانی | kobra shirani
department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

جواد بهروان | javad behravan
biotechnology research center and pharmacy school, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه مصفا | fatemeh mosaffa
biotechnology research center and pharmacy school, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مهرداد ایرانشاهی | mehrdad iranshahi
department of pharmacognosy and biotechnology, faculty of pharmacy, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

بابک mehmankhah | babak mehmankhah
department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

کمال رضوی azarkhiavi | kamal razavi azarkhiavi
department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

غلامرضا کریمی | gholamreza karimi
medical toxicology research center and pharmacy school, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_3040.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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