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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۳، صفحات ۲۱۸-۲۳۰
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عنوان انگلیسی Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil
چکیده انگلیسی مقاله Objective: Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. Materials and methods: Chemical composition of EOVAC was analyzed using gas chromatography – mass spectrometry (GC-MS) and also its possible toxicity was determined in mice. Analgesic effect of EOVAC was determined using tail immersion test, formalin test, and acetic acid-induced visceral pain in rats. Results: EOVAC (s.c.) and morphine (i.p.) significantly (p< 0.05) reduced pain responses in both formalin and tail immersion tests. In the study of evolved mechanisms, pretreatment with naloxone or atropine significantly (p < 0.05) reversed the essential oil-induced analgesia in both formalin and tail immersion tests. Moreover, EOVAC and Piroxicam produced significant (p< 0.05) inhibition in the acetic acid-induced writhing response.EOVAC did not show any mortality even at high dose (5 g/kg, p.o.) of administration in toxicity test. Moreover, according to GC-MS results, major components of the EOVAC were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%). Conclusions: These results suggest that endogenous opioidergic system as well as muscarinergic receptors of cholinergic system may be involve in the antinociceptive activity of Vitex agnus-castus essential oil in these models of pain in rats.
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نویسندگان مقاله عماد خلیل زاده | emad khalilzadeh
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

غلامرضا وفایی سیاح | gholamreza vafaei saiah
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

حمیده حسن نژاد | hamideh hasannejad
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

عادل قادری | adel ghaderi
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

شهلا قادری | shahla ghaderi
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

غلامرضا حمیدیان | gholamreza hamidian
division of histology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

رزاق محمودی | razzagh mahmoudi
department of food hygiene and aquatics, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

داود عشقی | davoud eshgi
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مهسا zangisheh | mahsa zangisheh
division of physiology, department of basic science, faculty of veterinary medicine, university of tabriz, tabriz, i.r.iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_4048.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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