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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۴، صفحات ۳۴۱-۳۵۴
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of Malva sylvestris cream on burn injury and wounds in rats
چکیده انگلیسی مقاله Objectives: Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowershave a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats. Materials and Methods: Five groups of 10 rats per group were burned with hot metal plate. Animals were administrated divided as control, normal saline, standard silver sulfadiazine 1% (SSD), 5% M. sylvestris, and 10% M. sylvestris into separate groups. Wound area, percentage of wound contraction, and histological and bacteriological assessments were evaluated. Results: Wound sizes were not significantly different among groups on 1st and 3rd days after burn injury, while they were significantly different among groups after 7th day post-burn injury. The average areas of wounds on the 15th day were 7.5±2.9, 6.7±2, 10.5±1.6, 4.7±2, and 4.5±2 cm2 for base cream, normal saline, SSD, 5% M. sylvestris, and 10% M. sylvestris, respectively. The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups. Microorganisms existed in the SSD group were most probably Staphilococcus epidermitis and for NS group were staphylococcus saprophiteccus. Conclusion: M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream. Therefore, it can be used as a topical treatment agent for burn wound.
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نویسندگان مقاله ابراهیم نصیری | ebrahim nasiri
traditional and complementary medicine research center, faculty of allied medical sciences, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سید جلال حسینی مهر | seyed jalal hosseinimehr
traditional and complementary medicine research center, faculty of pharmacy, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

محمد آزادبخت | mohammad azadbakht
traditional and complementary medicine research center, faculty of pharmacy, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

جعفر اکبری | jafar akbari
traditional and complementary medicine research center, faculty of pharmacy, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

رضا عنایتی فرد | reza enayati fard
department of pharmaceutics, faculty of pharmacy, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سهیل عزیزی | soheil azizi
department of laboratory medicine, faculty of allied medical sciences, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_4327.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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