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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۴، صفحات ۳۲۵-۳۳۲
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عنوان انگلیسی Anti-diabetic effect of Capparis spinosa L. root extract in diabetic rats
چکیده انگلیسی مقاله Objective: Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects of the C. spinosa root extract on diabetic metabolic disorders have been studied in experimental diabetes. Materials and Methods: Rats were divided into six groups: normal control (NC), diabetic control (DC), diabetic rats receiving 0.2, 0.4 g/kg of plant extract or 0.6 mg/kg glibenclamide (groups D0.2, D0.4 or DG respectively). A normal group of rats was also designed to receive 0.2 g/kg of plant extract (N0.2). Rats were rendered diabetic (streptozotocin 60 mg/kg, i.p.) and treated with 0.2, 0.4 g/ kg of plant extract or glibenclamide for four weeks. At the end of the experiment, blood was drawn through heart puncture under deep anesthesia. Weight was measured weekly, glucose levels were measured at the first and fourth week and lipid profiles, insulin and liver enzymes at the end of the study. Results: Glucose levels significantly decreased after treating with plant extract (p=0.003). However, insulin levels did not increase in any treating groups. Plant extract could significantly raise HDL and reduce levels of LDL and liver enzymes (ALT and ALP). Conclusion: These results showed that C. spinosa rootextract could improve diabetic related metabolic derangement such as hyperglycemia, dyslipidemia, and elevated liver markers in an insulin-independent manner.
کلیدواژه‌های انگلیسی مقاله Capparis spinosa, Diabetes Mellitus, Insulin, glibenclamide
نویسندگان مقاله مصطفی کاظمیان منصور آباد | mostafa kazemian mansur abad
department of biology, faculty of science, university of qom, qom, iran

سازمان اصلی تایید شده: دانشگاه قم (Qom university)

محمدرضا حایری | mohammad reza haeri
department of clinical biochemistry, faculty of medicine, qom university of medical sciences, qom, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

منصور ابراهیمی | mansoor ebrahimi
department of biology, faculty of science, university of qom, qom, iran

سازمان اصلی تایید شده: دانشگاه قم (Qom university)

رضا حیدری | reza heidari
anesthesiology section, qom university of medical sciences, qom, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_4317.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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