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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۵، صفحات ۴۵۰-۴۵۷
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عنوان انگلیسی Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats
چکیده انگلیسی مقاله Objectives: Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. Materials and Methods: A guide cannula was implanted into the fourth ventricle of brain in anesthetized rats. Orofacial pain was induced by subcutaneous (s.c.) injection of capsaicin (1.5 µg/20 µl) into the right vibrissa pad. The time spent face rubbing/grooming was recorded for a period of 20 min. Locomotor activity was measured using an open-field test. Results: Intra-fourth ventricle injection of crocin (10 and 40 µg/rat) and morphine (10 and 40 µg/rat) and their co-administration (2.5 and 10 µg/rat of each) suppressed capsaicin-induced orofacial pain. The analgesic effect induced by 10 µg/rat of morphine, but not crocin (10 µg/rat), was prevented by 20 µg/rat of naloxone pretreatment. The above-mentioned chemical compounds did not affect locomotor activity. Conclusion: The results of this study showed that the injection of crocin into the cerebral fourth ventricle attenuates capsaicin-induced orofacial pain in rats. The anti-nociceptive effect of crocin was not attributed to the central opioid receptors.
کلیدواژه‌های انگلیسی مقاله Crocin, Morphine, Naloxone, Orofacial pain, Rats
نویسندگان مقاله اسماعیل تمدن فرد | esmaeal tamaddonfard
division of physiology, department of basic sciences, faculty of veterinary medicine, urmia university, urmia, i.r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

سینا تمدن فرد | sina tamaddonfard
faculty of veterinary medicine, urmia azad university, urmia, i.r. iran


سالار پوربابا | salar pourbaba
faculty of veterinary medicine, urmia azad university, urmia, i.r. iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_4547.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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