این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۵، شماره ۵، صفحات ۴۱۳-۴۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Safety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophrenia
چکیده انگلیسی مقاله Objectives: Saffron is the stigma of Crocus sativus L., which has the potentials to play a role in the treatment of many diseases. Although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. This study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its major constituent) in adult patients with schizophrenia. Materials and Methods: The capsules of saffron aqueous extract (SAE) and crocin were used to evaluate short-term safety and tolerability in patients with schizophrenia. A double-blind, placebo-controlled study was performed on patients with schizophrenia. The patients were all male and were divided into three 22-patient groups. While receiving their normal treatment, they also received a 12 week treatment with SAE (15 mg twice daily), crocin (15 mg twice daily) or placebo. Results: A total of 61 patients completed the trial; none of them reported a serious side effect. WBC count increased significantly in patients receiving saffron aqua extract (SAE), but it was within the normal range and had no clinical significance. Other hematologic components, markers of thyroid, liver and kidney or inflammation markers had no statistically significant difference among the groups. Conclusions: This study showed that SAE and crocin in doses of 15 mg twice daily were safely tolerated in patients with schizophrenia.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله بنت الهدی موسوی | bentolhoda mousavi
department of psychiatry, university of social welfare and rehabilitation sciences, p.o.box 1985713834, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

سیده زهرا بطحایی | seyedeh zahra bathaie
department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, p.o.box 14115-111, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

فربد فدایی | farbod fadai
department of psychiatry, university of social welfare and rehabilitation sciences, p.o.box 1985713834, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

ذبیح اله اشتری | zabihollah ashtari
department of psychiatry, university of social welfare and rehabilitation sciences, p.o.box 1985713834, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

ندا علی بیگی | neda ali beigi
department of psychiatry, university of social welfare and rehabilitation sciences, p.o.box 1985713834, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

سارا فرهنگ | sara farhang
clinical psychiatry research center, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

سارا هاشم پور | sara hashempour
department of psychiatry, university of social welfare and rehabilitation sciences, p.o.box 1985713834, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

نسیم shahhamzei | nasim shahhamzei
department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, p.o.box 14115-111, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

حمید حیدرزاده | hamid heidarzadeh
department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, p.o.box 14115-111, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_3879.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات