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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۲، صفحات ۲۱۵-۲۲۲
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عنوان انگلیسی Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans
چکیده انگلیسی مقاله Objectives: The purpose of this study was to assay the antifungal activity of selected essential oils obtained from plants against both fluconazole (FLU)-resistant and FLU-susceptible C. albicans strains isolated from HIV positive patients with oropharyngeal candidiasis (OPC). Materials and Methods: The essential oils were obtained by hydrodistillation method from Myrtus communis (My. communis), Zingiber officinale roscoe (Z. officinale roscoe), Matricaria chamomilla (Ma. chamomilla), Trachyspermum ammi (T. ammi) and Origanum vulgare (O. vulgare). The susceptibility test was based on the M27-A2 methodology. The chemical compositions of the essential oils were obtained by gas chromatography- mass spectroscopy (GC-MS). Results: In GC-MS analysis, thymol (63.40%), linalool (42%), α-pinene (27.87%), α-pinene (22.10%), and zingiberene (31.79%) were found to be the major components of T. ammi, O. vulgare, My. communis, Ma. chamomilla and Z. officinale roscoe, respectively. The results showed that essential oils have different levels of antifungal activity. O. vulgare and T. ammi essential oils were found to be the most efficient (P< 0.05). The main finding was that the susceptibilities of FLU-resistant C. albicans to essential oils were higher than those of the FLU-susceptible yeasts. Conclusion: Results of this study indicated that the oils from medicinal plants could be used as potential anti- FLU-resistant C. albicans agents.
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نویسندگان مقاله عقیل شریف زاده | aghil sharifzadeh
mycology research center, faculty of veterinary medicine, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

حجت اله شکری | hojjatollah shokri
faculty of veterinary medicine, amol university of special modern technologies, amol, iran

سازمان اصلی تایید شده: دانشگاه تخصصی فناوری های نوین آمل (Amol university of special modern technologies)

نشانی اینترنتی http://ajp.mums.ac.ir/article_5372.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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