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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۲، صفحات ۱۸۱-۱۸۸
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat
چکیده انگلیسی مقاله Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina 750 mg/kg alone. R. canina (p.o., daily) and CCl4 (1 ml/kg twice a week, 50% v/v in olive oil, i.p.) were administered to animals for six weeks. Serum analysis was performed to assay the levels of aspartate aminotransferase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), albumin (ALB), total protein (TP) and malondialdehyde (MDA). Biochemical observations were also supplemented with histopathological examination (haematoxylin and eosin staining) of liver section.Results: Hepatotoxicity was evidenced by considerable increase in serum levels of AST, ALT, ALP, and lipid peroxidation (MDA) and decrease in levels of ALB and TP. Injection of CCL4 also induced congestion in central vein, and lymphocyte infiltration. Treatment with hydro-alcoholic fruit extract of R. canina at doses of 500 and 750 mg/kg significantly reduced CCl4-elevated levels of ALT, AST, ALP and MDA (p< 01). The extract also increased the serum levels of ALB and TP compared to CCl4 group (p< 01) at the indicated dose Histopathological studies supported the biochemical finding. Conclusion: our finding indicated hepatoprotective effects of the hydro-alcoholic fruit extract of R. canina on CCl4-induced hepatic damage in rats and suggested that theses effect may be produced through reducing oxidative stress.
کلیدواژه‌های انگلیسی مقاله hepatoprotective, Tetrachloride, Rosa canina fruit, Rats
نویسندگان مقاله هیبت اله صادقی | heibatollah sadeghi
medicinal plants research center, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

عبدالصالح حسین زاده | abdol saleh hosseinzadeh
student research committee, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

مهدی اکبرتبار طوری | mehdi akbartabar touri
social determinants of health research center, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

مهدی قوام زاده | mehdi ghavamzadeh
student research committee, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

مهرزاد جعفری برمک | mehrzad jafari barmak
cellular and molecular research center,yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

حسین صادقی | hossein sadeghi
department of pharmacology, faculty of medicine, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

مسلم سیاحی | moslem sayahi
student research committee, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_5481.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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