Iranian Journal of Neonatology، جلد ۴، شماره ۳، صفحات ۳۵-۴۱

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عنوان انگلیسی Could mean platelet volume predict developing of bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome?
چکیده انگلیسی مقاله Introduction: some studies have suggested correlation between MPV index and inflammatory diseases such as rheumatoid arthritis in adults. Though bronchopulmonary dysplasia is also an inflammatory disease which develops in preterm neonates with Respiratory distress syndrome, we decided to study the possible correlation between the mean platelet volume (MPV) and the occurrence of bronchopulmonary dysplasia (BPD) Subject & Methods: We reviewed the medical records of 280 infant with the diagnosis of RDS admitted to the neonatal intensive care unit of the Mahdieh obstetrics and gynecology Hospital of Tehran and Amir general Hospital of semnan from April 2008 to April 2012. Infants who have been expired before first month of life were excluded. Enrolled infants were divided into BPD and no-BPD groups (30 with and 250 without BPD). MPV was determined during first three days of life in all cases. Results: MPV measured during first three days of life was significantly( p=0.017) higher in the BPD than in the no-BPD group (10.8-0.96 versus 9.65-0.91 fL)but Platelet count at the same time were similar in the BPD and no-BPD groups, and MPV increment was associated with BPD development risk( (OR=1.6, 95%CI: 2.38-1.08, p=0.019) . Conclusion: We concluded that higher MPV in the first three days of life is a probable risk factor for the development of BPD in preterm infants with RDS. This might be attributed to the fact that high MPV could prone the neonate to inflammatory and oxidative lung damage. 
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نویسندگان مقاله شمس اله nourripoor | shamsollah nourripoor
department of pediatrics, amir-al-momenin hospital, semnan university of medical sciences , semnan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

حامد طبسی زاده | hamed tabasizadeh
department of pediatrics, amir-al-momenin hospital, semnan university of medical sciences , semnan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

ابوالفضل afjehi | abolfazl afjehi
department of neonatal care unit, mahdieh hospital, tehran university of medical sciences,tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

راهب قربانی | raheb ghorbani
department of social medicine ,semnan university of medical sciences , semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

مریم سیف هاشمی | maryam seifhashemi
department of pediatrics, amir-al-momenin hospital, semnan university of medical sciences , semnan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

نوشین مسعودیان | nooshin masoudian
department of neurology, imam reza hospital, tabriz university of medical sciences , tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)


نشانی اینترنتی http://ijn.mums.ac.ir/article_1752.html
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