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Iranian Journal of Neonatology، جلد ۵، شماره ۱، صفحات ۷-۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion |
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| چکیده انگلیسی مقاله |
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexplained abortions, and 10 women with at least two live births without a miscarriage were analyzed for MTHFR C677T polymorphism using PCR-RFLP (PCR-Restriction Fragment Length Polymorphism) method; the study was carried out on patients referring to Baqiyatallah Hospital and Avicenna Infertility Clinic. The results obtained via estimating the genotype of each polymorphism were analyzed by SPSS version 16. Results: Seventeen women (56.6 %) with recurrent spontaneous abortions and 5 women (50 %) from the control group were heterozygous for MTHFR C677T polymorphism. T-allele frequency in the experiment group was higher than the control group (28.4 % and 25 % for the experiment and control group, respectively). Conclusion: The prevalence of MTHFR C677T polymorphism was slightly higher in RSA patients compared with the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RSA in the evaluated Iranian women. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
امین خالق پرست | amin khaleghparast
m.sc. of biology-genetics, tehran science and research branch of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
شریف خالق پرست | sharif khaleghparast
b.eng. of industrial engineering, iran university of science and technology iust , tehran, iran
سازمان اصلی تایید شده: دانشگاه علم و صنعت ایران (Iran university of science and technology)
حسین خالق پرست | hossein khaleghparast
ph.d. of public law, tehran science and research branch of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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| نشانی اینترنتی |
http://ijn.mums.ac.ir/article_2350.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
تحقیقی اصیل |
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