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Iranian Journal of Neonatology، جلد ۵، شماره ۲، صفحات ۷-۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion |
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| چکیده انگلیسی مقاله |
Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage, who referred to Baqiyatallah Hospital and Avicenna Infertility Clinic, were analyzed for MTHFR A1298C polymorphism using PCR-RFLP method. The results obtained via estimating the genotype of each polymorphism were analyzed using SPSS v16. Results: Thirteen subjects (43.3 %) with RPL and 6 women (20 %) in the control group were heterozygous for MTHFR A1298C polymorphism. C allele frequency in the patient group was higher than the control group (41.7% and 40% for the patient and control groups, respectively). Conclusion: The prevalence of MTHFR A1298C polymorphism was slightly higher in RPL patients compared to the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RPL in the evaluated Iranian women. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
امین خالق پرست | amin khaleghparast
m.sc. of biology - genetics, science and research branch of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
شریف خالق پرست | sharif khaleghparast
b. eng. of industrial engineering, iran university of science and technology iust , tehran, iran
سازمان اصلی تایید شده: دانشگاه علم و صنعت ایران (Iran university of science and technology)
حسین خالق پرست | hossein khaleghparast
ph.d. in public law, science and research branch of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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| نشانی اینترنتی |
http://ijn.mums.ac.ir/article_2640.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
تحقیقی اصیل |
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