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Journal of Research in Medical Sciences، جلد ۹، شماره ۱، صفحات ۲۶-۰
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عنوان انگلیسی Comparison between Acute and Long-Term Effects of Verapamil on Naloxane Induced Morphine Withdrawal in Mice
چکیده انگلیسی مقاله Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice. Methods: Mice were rendered dependent on Morphine by subcutaneous injection of Morphine over a period of 5 days. The effects of acute and chronic administration of phenylalkylamine calcium channel antagonist, Verapamil, on Naloxone induced Morphine withdrawal signs was investigated. Results: A single injection of Verapamil proved to be effective in inhibiting some signs of Morphine withdrawal but ineffective in changing the number of jumps. The concurrent injections of Verapamil with Morphine prevented most signs of Morphine withdrawal. Conclusion: The results confirmed the crucial role of voltage-sensitive calcium channels in the adaptations that occur after long-term treatment with Morphine. Concurrent injections of Verapamil with Morphine could be used to prevent some signs of Morphine withdrawal.
کلیدواژه‌های انگلیسی مقاله Verapamil, Morphine withdrawal, Calcium antagonists
نویسندگان مقاله مسعود ربانی | m rabbani
department of pharmacology, school of pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

a جعفریان | a jafarian
department of pharmacology, school of pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

m سبحانیان | m sobhanian
department of pharmacology, school of pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/878
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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