این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۰، شماره ۵، صفحات ۲۸۱-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Premedication with oral Dextromethorphan reduces intra-operative Morphine requirement
چکیده انگلیسی مقاله Background: Intra-operative pain has adverse effects on hemodynamic parameters. Due to complications of opioids for pain relief, using non-opioids medication is preferred. The purpose of this study was to investigate the effect of oral dextrometorphan premedication on intra-operative Morphine requirement. Methods: After approval of the Ethics committee and informed consent, 40 adult patients who stand in American Society of Anesthesiologists Physical Status I and II, under general anesthesia for elective laparatomy were selected and classified in two equal groups randomly. In group A, oral dextromethorphan (60mg) was administered at 10 PM and 6 AM preoperatively. In group B, placebo (dextrose) was administered. After induction of general anesthesia and before skin incision, intravenous morphine (0.01 mg/kg) was administered. During surgery, when systolic blood pressure or heart rate was increased more than 20% of the preoperative baseline, 0.01 mg/kg morphine was administered. At the end of surgery, the totally prescribed morphine (mg/kg) and maximal increase in systolic, diastolic, mean arterial blood pressure and heart rate relative to the baseline values were calculated and statistically compared with student’s t-test. Results: The mean dose of administered morphine during surgery was significantly less in group A than group B (P< 0.0001). Also, Maximal increase in systolic, diastolic and mean arterial blood pressure was significantly less in group A (p< 0.003, p< 0.004, p< 0.0001, respectively). There was no significant difference in maximal heart rate increase between two groups (p< 0.114). Conclusion: Oral dextromethorphan premedication may decrease intra-operative morphine requirement and reduce maximal increase in systolic and mean arterial blood pressure during surgery.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله r طلاکوب | r talakoub
assistant professor, department of anesthesiology, isfahan university of medical science, isfahan

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

f molaeinasabmd | f molaeinasabmd
resident, department of anesthesiology, isfahan university of medical science, isfahan

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/65
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات