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Journal of Research in Medical Sciences، جلد ۱۱، شماره ۱، صفحات ۶-۰
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عنوان انگلیسی The Relationship between Random Urinary Protein-to-Creatinine Ratio and 24-hours Urine Protein in Diagnosis of Proteinuria in Mild Preeclampsia
چکیده انگلیسی مقاله Background: The purpose of this study was to evaluate whether a random urinary protein / creatinine ratio is a clinically useful predictor of significant proteinuria (300 mg/24 hr) instead of 24- hours urine protein, among women with suspected preeclampsia. Methods: Women with suspected preeclampsia and gestational age of 20 weeks were included in a prospective study. Patients with chronic hypertension, diabetes mellitus, or preexisting renal disease were excluded. Protein/ creatinine ratio was obtained before 24-hours urine collection. Positive and negative predictive values and sensitivity and specificity of the protein/creatinine ratio for significant proteinuria (300 mg) were calculated, based on 24-hours urine total protein. Results: 100 women were evaluated totally. Mean maternal and gestational ages were 27.3 years and 33.26 weeks, respectively.73% of cases had significant proteinuria based on 24-hours urine collection. Good correlations were found between the protein/creatinine ratio in random urine samples and both the 24-hours urine protein excretion and the 24- hours urine protein/creatinine ratio in patients with mild preeclampsia (r=0.484, P 0.18 which yields a sensitivity of 86.3%, a specificity of 100%, with a positive predictive value of 100%, and a negative predictive value of 73%. Conclusion: The random urinary protein –to- creatinine (P: C) ratio is strongly associated with the 24-hours total protein excretion. A cutoff value of > 0.18 is a good predictor of significant proteinuria .P: C ratio could replace the 24- hours urine collection as a simpler, faster, and more accurate method for the diagnosis of significant proteinuria.
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نویسندگان مقاله aa طاهریان | aa taherian
professor, department of obstetrics and gynecology, isfahan university of medical sciences, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

s دهباشی | s dehbashi
associated professor, department of obstetrics and gynecology, shiraz university of medical sciences, shiraz

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

m باغبان | m baghban
resident, department of obstetrics and gynecology, isfahan university of medical sciences, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/93
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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