| چکیده انگلیسی مقاله |
BACKGROUND: Insulin-like growth factor 1 (IGF-I) is an anabolic growth factor that affects nitrogen balance and its changing trend is not clearly understood in critically ill patients. This study was carried out to evaluate the association between serum IGF-I levels and its changing trend in critically ill patients. METHODS: In this nested case-control study, all consecutive patients admitted to the medical ICU of Rasoul-e-Akram and Firuzgar hospital (Tehran, Iran) from January through October 2008 were included. IGF1 concentration was measured within the first 24h of ICU admission and the fourth, seventh and tenth day since admission. Patients were followed until discharge from ICU or expiration. RESULTS: The study population consisted of 90 patients (mean age: 58.01 ± 22.56), 31 (34.4%) of who died and 59 (65.6%) were discharged. On admission, 43 patients (47.7%) had low IGF-I levels, whereas 47 (52.3%) had normal or high levels. The concentration of IGF-I was not significantly different in every 4 measurements between expired and discharged patients. Significant decrease was seen between first to fourth day IGF-I concentration (p = 0.005). Changing trend was not statistically different in two groups of patients. CONCLUSIONS: There was no relation between low IGF-I concentration on admission day and increased adverse outcome, but overall these patients had lower IGF1. No clear association was found between changing trend of IGF1 and mortality. Stress on admission time may cause decreasing pattern of IGF-I in the first 4 days of admission. KEYWORDS: Intensive Care Units, Critical Illness, Insulin-Like Growth Factor I, Mortality. |
| نویسندگان مقاله |
شکوفه حاج صادقی | shokoufeh haj sadeghi
md, tehran university of medical sciences, rasoul-e-akram hospital, department of cardiology, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد ابراهیم خمسه | mohammad ebrahim khamseh
md, tehran university of medical sciences, firuzgar hospital, institute of endocrinology and metabolism, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سعید غلامی | saied gholami
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
اسکات رضا جعفریان کرمان | scott reza jafarian kerman
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
گلنار گوهردهی | golnar gohardehi
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
نگار سیفی مقدم | negar seifi moghaddam
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
آزاده شفیعی ثابت | azadeh shafiee sabet
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مسعود مرادی | masoud moradi
medical student, tehran university of medical sciences, faculty of medicine, medical student research committee, cardiology field, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
رضا ملاحسینی | reza mollahoseini
iran university of medical sciences. firozagar hospital, department of neurosurgery
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
مهری نجفی | mehri najafi
iran university of medical sciences, firozagar hospital, institute of endocrinology and metabolism
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
momahhad رضا کرامتی | momahhad reza keramati
tehran university of medical sciences, firuzgar hospital, department of general surgery, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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