این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۰، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Treadmill running improves spatial learning and memory in the rats with intracerebroventricular injection of streptozotocin
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Exercise has positive effects on central nervous system, especially when there is a context of disorder. 1 Considering the prevalence of Alzheimer’s disease and lack of a decisive treatment, this study aimed to evaluate the effect of exercise on learning and memory in rats after intracerebroventricular injection of streptozotocin (ICV-STZ), a well defined model for Alzheimer’s disease . 2 Experimental groups consisted of sham-rest, sham-exercise, lesion-rest and lesion–exercise groups. Rats in lesion group received ICV-STZ. In the exercise group, rats were made to run on a treadmill (20 m/min, 0-degree inclination, 50 min/day, 4 weeks). Morris water maze test was used to evaluate spatial learning and memory. The results showed that spatial learning and memory indices were significantly impaired in the rats with ICV-STZ (Figure 1). However, exercise prevented impairments as there was a significant difference between lesion–exercise and lesion–rest groups. The findings of this study suggested that similar to Alzheimer’s disease, ICV-STZ severely impairs cognitive process, but exercise prevents this damage. Therefore, exercise probably is helpful in prevention and alleviation of cognitive disorders in Alzheimer’s disease. KEYWORDS: Alzheimer, Treadmill Running, Streptozotocin, Spatial Learning and Memory, Morris Water Maze.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهدیه یوسفی | mahdieh yosefi
student, department of basic sciences, isfahan payame noor university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

پرهام رییسی | parham reisi
assistant professor, biosensor research center and department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حجت اله علایی | hojjatallah alaei
professor, department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی اصغر پیله وریان | ali asghar pilehvarian
assistant professor, department of basic sciences, isfahan payame noor university, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

بهمن رشیدی | bahman rashidi
assistant professor, department of anatomical sciences and molecular biology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7528
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Letters to Editor
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات