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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱۰، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Can serum procalcitonin and C-reactive protein as nosocomial infection markers in hospitalized patients without localizing signs?
چکیده انگلیسی مقاله 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND: Early diagnosis of infection with the use of valuable markers leads to decreased mortality and morbidity. The aim of this study was to evaluate the value of procalcitonin (PCT) and C-reactive protein (CRP) for detecting nosocomial infection in hospitalized patients without localizing signs. METHODS: We conducted a prospective observational study on 150 hospitalized patients with fever > 38ºC emerging 48-72 hours after their admission at Alzahra Hospital, Isfahan, Iran. The subjects did not have any localizing sign of infection. PCT and CRP values were determined using rapid tests and were compared with results of blood culture as the standard test. The sensitivity, specificity, positive and negative predictive values (PV) and likelihood ratios (LRs) were calculated for both PCT and CRP. Receiver operating characteristic (ROC) curves were also used to evaluate the diagnostic value of the PCT and CRP for detecting nosocomial infections. Finally, the areas under the resulting curves were compared. RESULTS: PCT had a sensitivity of 57.1%, a specificity of 89.1%, a positive PV of 46.2%, and a negative PV of 92.7% while the corresponding percentages for CRP test were 76.2%, 48%, 19.3%, and 92.5%. PCT marker also had a higher positive LR and lower negative LR than did CRP marker. The observed areas under the ROC curves were 0.73 for CRP (95% CI, 0.63-0.82; p = 0.023) and 0.80 for PCT (95% CI, 0.68-0.91; p = 0.001). The optimal cut-off values (best diagnostic accuracy) were 39 mg/L for CRP and 7.5 ng/mL for PCT. CONCLUSIONS: Determination of PCT and CRP is a valuable tool for identifying nosocomial infections. PCT showed better specificity, negative and positive PV. However CRP showed significantly better sensitivity compared with PCT. Therefore, these tests should be considered as part of initial work-up for patients with unknown source of infection.
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نویسندگان مقاله فرزین خوروش | farzin khorvash
associate professor, infectious diseases research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فاطمه عبدی | fatemeh abdi
msc of midwifery, medical students research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

کورش دیالمه | korosh dialame
specialist, departmentof infection diseases, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی محرابی کوشکی | ali mehrabi kooshki
department of epidemiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7060
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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