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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
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عنوان انگلیسی Irritable bowel syndrome–like symptoms are re-lated to gut inflammation in clinical remission phase of inflammatory bowel disease
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND: Symptoms consistent with irritable bowel syndrome (IBS) are common among patients with inflammatory bowel disease (IBD) in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of fecal calprotectin (FC) could be helpful in this regard. METHODS : The study population consisted of 42 IBD patients in remission that fulfilled the IBS diagnostic criteria (Rome III), 24 IBS patients, and 30 healthy controls. Clinical remission was determined based on physician’s assessments, not using corticosteroids or biological agents within the preceding six months and activity indices. The FC and C-reactive protein (CRP) levels were investigated and compared among the groups. RESULTS: FC levels were significantly higher in patients with IBD (142.9 ± 216.5 µg/g) than those with IBS (24.9 ± 27.8 µg/g) and controls (17.9 ± 14.8 µg/g) (p < 0.001). CRP levels were also higher in IBD than IBS patients [3.9 (SE = 0.5) vs. 2.1 (SE = 0.5), p = 0.030]. However, FC levels were not significantly correlated with CRP levels or with severity of symptoms in IBD and IBS patients (p > 0.05). CONCLUSIONS: The presence of IBS-like symptoms in IBD patients in clinical remission may reflect an ongoing activity of IBD, which is undetectable by current activity indices. Serum CRP levels are not specific enough in such situation, and FC is a more accurate and specific test for investigating mucosal inflammation in this regard. KEYWORDS: Inflammatory Bowel Disease, Crohn’s Disease, Ulcerative Colitis, Remission, Inflammation, Irritable bowel syndrome
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نویسندگان مقاله حمید توکلی | hamid tavakkoli
associate professor, integrative functional gastroenterology center and department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مریم haghdani | maryam haghdani
resident of internal medicine, department of gastroenterology, alzahra university hospital and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سعید haghdani | saeid haghdani
resident, department of urology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منیره توکلی | monireh tavakkoli
research assistant, integrative functional gastroenterology center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حامد دقاق زاده | hamed daghaghzadeh
assistant professor, integrative functional gastroenterology center and department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی غلامرضایی | ali gholamrezaei
research assistant, poursina hakim research institute, isfahan, iran


پیمان ادیبی | peyman adibi
professor, integrative functional gastroenterology center and department of gastroenterology, alzahra university hospital, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8220
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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