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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Effect of L-Arginine and L-NAME on coronary angiogenesis in male diabetic rats
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} BACKGROUND : Diabetes is associated with several vascular abnormalities due to abnormal angiogenesis. Vascular endothelial growth factor (VEGF) and nitric oxide (NO) are among the most important angiogenic factors. The aim of this study was to evaluate the effect of L-arginine (L-Arg) and L-NAME on coronary angiogenesis in male diabetic rats. METHODS : 24 male rats were randomly divided into four groups: (1) control, (2) diabetic, (3) diabetic + L-Arg (50mg/kg/day, ip), (4) diabetic + L-NAME. (10mg/kg/day, ip). After three weeks, blood samples were taken and the apex of the hearts was stained for immunohistochemistry. RESULTS : Coronary angiogenesis expressed as capillary density/mm2 was lower in diabetic group compared to the control group (P Ë‚ 0.05). L-Arg significantly improved capillary density in myocardial tissue in diabetic animals (P Ë‚ 0.05); however, L-NAME did not alter it (P ˃ 0.05). CONCLUSIONS : It seems that L-Arginine improves coronary angiogenesis in type I diabetic animals through changes of serum angiogenic factors. More studies are needed to clarify the effect of NO agonists in different experimental models of angiogenesis. KEYWORDS : L-Arginine, L-NAME, Diabetes, Angiogenesis
کلیدواژه‌های انگلیسی مقاله L-Arginine, L-NAME, Diabetes, Angiogenesis
نویسندگان مقاله مجید خزایی | majid khazaei
associate professor, department of physiology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد امین مشیدی | muhammad amin moshayedi


مسعود تیموری جروکانی | massoud teimouri jervekani
student, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهرزاد عقیلی | shahrzad aghili
student, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سعید منتظری | saeed montazeri
student, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

روشنک مهدی پور دستجردی | roshanak mehdipour dastjerdi
student, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فضل اله هاشم زهی | fazlolah hashemzehi


hourossadat هاشمی جزی | hourossadat hashemi jazi
student, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8222
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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