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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۷، صفحات ۰-۰
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عنوان انگلیسی The effect of quercetin supplementation on selected markers of inflammation and oxidative stress
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA MicrosoftInternetExplorer4 Background: Athletes use flavonoids as antioxidant to enhance endurance and physical performance. In vitro data indicate flavonoids have antioxidative and antiinflammatory functions but data in human studies are limited. The aim of this study was to determine the effects of a 2-month flavonoid quercetin supplementation on oxidative stress and inflammatory biomarkers in nonprofessional athletes with regular exercise. Materials and Methods: The randomized double-blind clinical trial was done among subjects with systematic and regular exercise for 8 weeks in four groups, each containing 15 individuals: 500 mg quercetin + 250 mg vitamin C as pro-oxidant (Q+C), 500 mg of quercetin alone (Q), 250 mg of vitamin C alone (C), and placebo (Control). IL-6, CRP, E-selectin and F2-isoprostane were measured before and after intervention. Results: In 60 participants with mean (±SD) age of 21.0 ± 1.6 years, statistically significant within group differences were observed in IL-6 (P< 0.1), CRP (P< 0.01) and F2-isoprostane for group 1 and pre- and postchanges in E-selectin was marginally significant for all study groups (P< 0.1). Group 1 had marginally smaller F2-isoprostane (P< 0.1) and interleukin 6 than control group (P< 0.05) and there were marginally differences in CRP between respondents in group 1 and 2 with the control group (P< 0.1). Conclusions: Eight-week supplementation with quercein-vitamin C was effective in reducing oxidative stress and reducing inflammatory biomarkers including CRP and IL-6 with little effect on E-selectin in healthy subjects.
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نویسندگان مقاله غلامرضا عسکری | gholamreza askari
department of community nutrition, school of nutrition and food sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رضا غیاثوند | reza ghiasvand
department of community nutrition, school of nutrition and food sciences and food security research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

آوات فیضی | awat feizi
department of biostatistics and epidemiology, school of health, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سید مصطفی قنادیان | syed mustafa ghanadian
isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

جهانگیر کریمیان | jahangir karimian
faculty of management and medical information, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8508
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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