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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۸، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Synergistic effects of genetic polymorphism and air pollution on markers of endothelial dysfunction in children
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: This study aims to determine the association of some genetic polymorphisms in the relationship of air pollutants on the serum levels of thrombomodulin (TM) and tissue factor (TF) in a population-based sample of children and adolescents. Materials and Methods: This cross-sectional study was conducted among 110 participants (52.8% girls) with a mean age of 12.7 + 2.3 years, in Isfahan, Iran. Genotypes of TM G33-A and + 5466A > G polymorphisms were determined by the polymerase chain reaction – restriction length fragment polymorphism method (PCR-RFLP). The enzyme-linked immunosorbent assay (ELISA) was used for measurement of serum TM and TF. Results: The following genotypes were identified for TM: GG in 69.2%, GA in27.2%, and AA in 3.6% of the participants. Considering TF, 108 participants were homozygous for the + 5466A allele, and two subjects had + 5466AG genotype. The mean pollution standards index (PSI) value was at a moderate level; the mean particulate matter measured up to 10 μm (PM10); and ozone (O3), nitrogen dioxide, and sulfur dioxide were considerably high. The mean serum TF and TM levels were not significantly different among the participants with the aforementioned genotypes. Among participants exposed to high quartiles of O3, PM10, and PSI, the TM-33G / A polymorphism (GA + AA genotype) increased the Odds ratio (OR) of the low serum TM level. There was no statistically significant association in the areas of low pollution. Conclusion: The findings of our study support the synergistic effect of the TM-33G / A polymorphism and air pollutants on factors associated with the onset of the atherosclerosis. This might be confirmatory evidence for gene-environment interaction, and related effects on atherogenesis from early life.
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نویسندگان مقاله پریناز پورصفا | parinaz poursafa
department of environment protection, environment research center, isfahan university of medical sciences iums , isfahan,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رویا کلیشادی | roya kelishadi
department of pediatrics, school of medicine and child growth and development research center, iums,isfahan, iran


شقایق حقجو جوانمرد | shaghayegh haghjooy javanmard
department of physiology, applied physiology research center, iums, isfahan, iran


لاله رفیعی | laleh rafiei
department of physiology, applied physiology research center, iums, isfahan, iran


کسری keramatian | kasra keramatian
child growth and development research center, iums,isfahan, iran
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8566
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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