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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۹، صفحات ۰-۰
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عنوان انگلیسی Defining the at risk patients for contrast induced nephropathy after coronary angiography; 24-h urine creatinine versus Cockcroft-Gault equation or serum creatinine level
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 BACKGROUND: Definitions of chronic kidney disease (CKD) in many catheterization laboratories have relied on the serum creatinine (Scr) rather than glomerular filtration rate (GFR). Regarding that CKD is the primary predisposing factor for contrast induced nephropathy (CIN), we compared the sensitivity of calculated GFR by 24-h Urine creatinine with Cockcroft-Gault (CG) equation and Scr level to define at risk patients for CIN who were undergone coronary angiography (CAG). MATERIALS AND METHODS: Two hundred fifty four subjects who were candidate for CAG and had normal creatinine level were enrolled. Before CAG, GFR was calculated from a 24-h urine collection, CG equation and a single Scr sample regarding to previously described protocol. Contrast volume used for each case < 100 ml. CIN was defined as a 0.5 mg/dL or 25% elevation in the Scr. RESULTS: CIN occurred in 10.6%. Baseline GFR, the volume of contrast agent, and diabetes were the independent risk factors for CIN. GFR was less than 60 ml/min/1.73 m 2 in 28% and 23.2% of patients regarding to 24-h urine creatinine and CG equation, respectively. In CIN prediction, 24-h urine creatinine estimated GFR had 85.2%, 59.3% and CG equation GFR had 78.9%, 81.1% sensitivity and specificity, respectively. CONCLUSION: Although, GFR estimated by CG equation has less sensitivity than GFR calculated from 24-h creatinine in CIN probability, but it is better than Scr alone and because of cost-effectiveness and convenience using of this method, we suggest at least using CG equation for GFR calculation before CIN, especially in diabetic and/or older than 60 years cases.
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نویسندگان مقاله احمدرضا عصاره | ahmadreza assareh
cardiovascular research center, ahvaz jundishapur university of medical science, golestan hospital, ahvaz, iran


سعید یزدانخواه | saeed yazdankhah
cardiovascular research center, ahvaz jundishapur university of medical science, golestan hospital, ahvaz, iran


احمد احمدزاده | ahmad ahmadzadeh
hematology ward, ahvaz jundishapur university of medical science, golestan hospital, ahvaz, iran


دکتر مهدی یداله زاده | mahdi yadollahzadeh
department of internal medicine, shahid beheshti university of medical sciences sbmu , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نسیم ناصحی | nasim nasehi
cardiovascular research center, ahvaz jundishapur university of medical science, golestan hospital, ahvaz, iran


حبیب حی بر | habib haybar
cardiovascular research center, ahvaz jundishapur university of medical science, golestan hospital, ahvaz, iran
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8622
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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