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Journal of Research in Medical Sciences، جلد ۲۰۱۴، شماره ۰۱، صفحات ۰-۰
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عنوان انگلیسی Effects o Pulsed Electromagnetic Field on Intervertebral Disc Cell Apoptosis in Rats
چکیده انگلیسی مقاله Background: Despite numerous studies on pulsed electromagnetic field (PEMF) application, the effects of PEMF on intervertebral disc (IVD) have not yet been investigated in vivo. Materials and Methods: Accordingly, the effects of PEMF upon IVD in rats were evaluated through molecular surveys. Rats were divided into six groups: Group I and II were exposed to low and high frequency of PEMF (LF and HF respectively). Group III and IV underwent induced disc degeneration and were exposed to low and high frequency of PEMF (LF/IDD and HF/IDD, respectively). Group V underwent induced disc degeneration (IDD), and group VI was control. The values of caspase 3, Bax, Bcl-2 and β-actin band density, as cell apoptotic markers, were obtained from band densitometry. Results: Our results showed that the value of cleaved Caspase-3 of cells and Bax/Bcl-2 ratio in IDD group increased significantly compared to the control group (p< 0.001).The value of cleaved Caspase-3 and Bax/Bcl-2 ratio decreased significantly in LF/IDD and HF/IDD groups compared to IDD group (P< 0.05). No significant increase was seen in the cell apoptotic markers in the groups just exposed to PEMF compared to the control group. There was also no significant decrease in the Bax/Bcl-2 ratio in HF/IDD and LF/IDD groups compared to the control group. Conclusion: These data suggest that PEMF attenuates degenerative processes in rat's intervertebral discs and has no effect on normal discs. Regulations of the expression of apoptotic proteins may be one of the mechanisms by which PEMF is effective in reduce disc degeneration. Normal 0 false false false EN-US X-NONE AR-SA
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نویسندگان مقاله حامد ریحانی کرمانی | hamed reihani kermani
department of neurosurgery, kerman university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

مهدی پورقاضی | mehdi pourghazi
department of neurosurgery, kerman university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

اسماعیلی ماهانی | saeed esmaeili mahani
department of neurosurgery, kerman university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9703
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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